Low Levels of Serotonin a Cause of Sudden Infant Death Syndrome?

Sudden Infant Death Syndrome (SIDS) is the third leading cause of infant death with over 2000 lives being taken every year. 

A new study funded by the NIH through the National Institute of Child Health and Human Development (NICHD) found that serotonin levels were 26 percent lower in tissue from infants who died of SIDS than in tissue from the group of infants who died unexpectedly in ways unrelated to SIDS. Serotonin is a brain chemical that plays a vital role in regulating breathing, heart rate, and sleep.  The study also measured tryptophan hydroxylase, an enzyme needed to make serotonin, and found that these enzyme levels were 22 percent lower.

The findings of this study are published in the Feb. 3 issue of The Journal of the American Medical Association. Senior author Dr. Hannah C. Kinney, M.D., of Harvard Medical School and Children’s Hospital Boston, and her colleagues examined small samples of tissue from the medulla, a region at the base of the brain that regulates basic functions such as body temperature, breathing, blood pressure, and heart rate. 

Alan E. Guttmacher, M.D., acting director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) says, “We have known for many years that placing infants to sleep on their backs is the single most effective way to reduce the risk of SIDS… The current findings provide important clues to the biological basis of SIDS and may ultimately lead to ways to identify infants most at risk as well as additional strategies for reducing the risk of SIDS for all infants.”

The findings indicate that the brains of infants who die of sudden infant death syndrome (SIDS) produce low levels of serotonin.
About Sudden Infant Death Syndrome

SIDS is the death of an infant before his or her first birthday that cannot be explained after a complete autopsy, an investigation of the scene and circumstances of the death, and a review of the medical history of the infant and of his or her family. According to the National Center for Health Statistics, SIDS is the third leading cause of infant death (http://www.cdc.gov/NCHS/data/nvsr/nvsr57/nvsr57_14.pdf), claiming more than 2,300 lives in 2006.

The researchers theorize that this newly discovered serotonin abnormality may reduce infants’ capacity to respond to breathing challenges, such as low oxygen levels or high levels of carbon dioxide. These high levels may result from re-breathing exhaled carbon dioxide that accumulates in bedding while sleeping face down. T

NICHD’s Back to Sleep (http://nichd.nih.gov/sids/) campaign urges parents and caregivers to place infants to sleep on their backs. Following the campaign’s launch in 1994, the rate of SIDS dropped by more than 50 percent. Widespread adoption of back sleeping appears to have reduced the occurrence of SIDS, but has not eliminated it.

Study Size

The researchers analyzed brain tissue from infants who died from SIDS and controls who died of other causes. Included in the analysis were 35 infants who died of SIDS, 5 infants who died unexpectedly of other causes, and 5 infants who were hospitalized and died for reasons associated with a lack of oxygen.

More Information

Information on reducing the risk of Sudden Infant Death Syndrome is available on the NICHD Web site (http://www.nichd.nih.gov/health/topics/Sudden_Infant_Death_Syndrome.cfm).

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